US-MA-Cambridge: Principal Scientist Discovery Biology

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Date: 17-Feb-2009

Principal Scientist - Discovery Biology

Description:

Seeking a scientist with a strong background in cancer cell metabolism and/or targeted therapies for cancer to help lead our drug discovery program. The successful candidate will help direct our efforts to identify promising drug targets and oversee in-house target validation and drug screening programs based around them. As such you will play a key role in developing our pipeline of oncology drugs.

Responsibilities:

* Oversee a group of biologists and liaise with chemistry and informatics groups to develop an efficient drug discovery operation with the overall responsibility of producing a steady flow of oncology drug candidates * Targets of interest include kinases and enzymes involved in cancer cell metabolism and signaling * The group you oversee will be responsible for: o Conducting a broad array of studies to validate promising cancer targets o Developing and carrying out in vitro and cellular screening assays to identify potent inhibitors o Conducting studies to determine the mechanism of action of compounds with promising anti-cancer activity, leading to nomination of compounds for clinical development

Job Requirements:

* PhD in Genetics, Molecular Biology or a related field with a minimum of 9 years of additional research experience; * A minimum of 2 years’ industry experience is absolutely required. Candidates without industry experience will not be considered. * Strong background in oncology/cancer research, with advanced understanding of signaling pathways implicated in disease, including pathways involved in cancer cell metabolism * Experience using a broad range of technologies to study disease targets, including RNAi, proteomic and genomic approaches * A very high level of motivation and a proven record of accomplishment (e.g. a strong publication record in top-tier journals) * Excellent managerial skills and the ability to work effectively as part of a team * Outstanding written and oral communication skills

To apply for this position, please visit this Website.

Thank you,
BioTech FYI Center
http://biotech.fyicenter.com/