US-CA-Valencia: Sr Scientist Computational Chemistry

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Date: 18-Mar-2008

Sr Scientist Computational Chemistry

In this senior scientist position, the candidate will play a significant role in the generation of lead compounds for various medicinal chemistry programs. In this role you will apply structure-based design principles to guide chemistry efforts, with an emphasis on utilizing docking techniques, developing fragment-based or scaffold-hopping approaches. Assist in compound design and library design for target- and class-specific hit generation. The individual will collaborate/interact with a broad group of scientists within us and with external collaborators. Close interactions with discovery biology, translational medicine, exploratory pharmacology, bioinformatics and formulation groups is expected. The candidate should have a strong background in synthetic organic chemistry and medicinal chemistry with an emphasis on in silica modeling and design.

Requirements

Candidates are required to have a Ph.D. in synthetic organic or medicinal chemistry with a minimum of 4 years of industrial or postdoctoral experience, and have an excellent understanding of protein-ligand interactions. An understanding of principles in conformational analysis Expert use of commercial modeling software, and the ability to mentor others in its use, will be expected. Familiarity with medicinal chemistry software tools such as Schrodinger, Accelrys, SciTegic, Pipeline Pilot, Spotfire, ActivityBase, and Daylight is advantageous. Knowledge of the Linux operating system is desirable. Familiarity with the discovery and advancement of IND-ready drug candidates, experience with patenting and publishing, and a "lead-by-example" drug discovery approach is desirable. Excellent written and verbal communication skills are required.

• Ph.D. in synthetic organic or medicinal chemistry • 2 - 4 years of relevant experience in the pharmaceutical or academic environment • Proven track record of innovation including peer-reviewed publications and/or patents • Ability to work independently and ability to interact with a multidisciplinary team of medicinal chemists, biologists, pharmacologists and external collaborators. • Experience with structure-based drug design. • Excellent oral / written communication and presentation skills • Flexibility to work in a dynamic environment

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BioTech FYI Center
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