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US-MA-Cambridge: Senior Scientist, Biochemistry

Date: 05-Nov-2013
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Senior Scientist, Biochemistry

Looking for a senior scientist who is passionate about exploring the potential for leveraging epigenetics to create life-changing therapies for patients with neurodegenerative, inflammatory, hematologic and fibrotic diseases.

Extensive experience with isolation of biomolecules, including protein-protein and protein-nucleic acid complexes, and protein purification Proven experience with mammalian, fungal and bacterial cell growth for production and isolation of proteins and nucleic acids Knowledge of affinity purification techniques for isolation of biomolecules Experience with isolation of nucleic acids in support of transcriptomic, genomic and epigenomic analyses Experience with biochemical assay development to understand protein activity, and protein-protein and protein-nucleic acid interaction Background in physical biochemistry including catalytic mechanisms, binding kinetics and affinity, molecular docking Experience withInterest in methods development, e.g., affinity capture, protein-protein interaction, protein-nucleic acid interaction preferred Familiarity with chemical, biochemical and biological data Willingness to engage and ability to coordinate multiple collaborative projects within a cross-functional team environment Highly self-motivated, with excellent organizational, and oral and written communication skills Experience in training, mentoring and managing junior colleagues Experience with LIMS a plus Relevant publications in peer-reviewed journals expected in support of candidacy Demonstrates independent scientific thinking, and solves complex technical and scientific problems with significant impact on major drug discovery and development projects

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