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US-MA-Waltham: Staff Scientist in Biotech

Date: 22-Feb-2011
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Staff Scientist - Protein Chemistry

KEY DUTIES: • Lead characterization efforts for candidate lead proteins; development and execution of analytical and biochemical assays. • Plan comprehensive studies; manage, analyze, and interpret data • Research and recommend purchase of capital equipment as appropriate and required. • Interface with external resources to augment internal capabilities • Adapt new technologies and identify proprietary opportunities

TECHNICAL SKILLS:

• Laboratory experience in protein expression, purification, and biochemistry and biophysics techniques, including, but not limited to SDS-PAGE, Western Blotting, ELISA, in vitro activity assays, glycoform analysis, LC-MS, ITC, FRET, FP, SPR, NMR, equilibrium dialysis, protein ultracentrifugation. • In depth understanding of enzyme kinetics and protein thermodynamics. • Experience with protein structure-function, molecular modeling, and protein engineering. • Strong understanding of experimental design principles and statistics • Experience supporting protein therapeutic discovery in an industrial setting • Familiarity with protein therapeutic drug development (formulation, manufacturing, clinical)

PERSONAL SKILLS: • Committed to maintaining high standards in quality of science • Strong sense of urgency; ability to work at a fast pace under aggressive timelines • Proactive, Motivated, adaptable self starter; able to muti-task • Strong collaborator, ability to work in a team setting • Critical, analytical thinker • Strong communication and organizational skills

MINIMUM EDUCATION AND EXPERIENCE • PhD in a relevant scientific discipline (chemistry, biochemistry, biophysics) with 6+ years of experience in the pharmaceutical/biotechnology industry

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