Biotech > Glossary

Microarray Glossary

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Lab-on-the-chip
Microfabricated system for performing biochemical assays such as e.g. capillary electrophoresis, probe preparation, PCR reactions (microfluidics-based chips)


LCM
Laser Capture Microdissection conceived and first developed as a prototype research tool at the National Institute of Child Health and Human Development (NICHD) and the National Cancer Institute (NCI) of the National Institutes of Health (NIH). LCM was developed into a commercial laboratory instrument by Arcturus Engineering, Inc. and the NIH.


Linkage
Tendency for some parental alleles to be inherited together (opp. Mendel's law).


Linkage disequilibrium
Describes a condition in which certain alleles at two linked loci are nonrandomly associated with each other. This might be either because of very close physical proximity or because the combination is under some kind of selective pressure.


LNA
Locked nucleic acid; a novel class of nucleic acid analogues. LNA monomers are bicyclic compounds that are structurally similar to RNA nucleosides; the term LNA refers to the observation that the furanose ring conformation is restricted in LNA by a methylene linker that connects the 2'O position to the 4'-C position. Therefore, all nucleic acids that contain one or more LNA modifications are called LNA. Duplexes formed with either DNA or RNA have a very high thermal stability (approximately 3C to 8C per modified base higher).


Locus
Position on a chromosome that is occupied by a particular gene

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