Collections:
What Are PK Related Terminologies
What Is PK (Pharmacokinetic) Related Terminologies?
✍: Guest
Here are main PK (Pharmacokinetic) related terminologies
as shown in this FDA picture:
Drug Concentration - Drug Concentration is usally measured as the amount of the drug in a unit of blood volumn.
Cmax (maximum concentration) - Cmax is the highest concentration of drug in the blood that is measured after the drug is taken.
Tmax - Tmax is the time to reach the Cmax after the drug is taken.
Cmin (minimum concentration) - Cmin is the lowest concentration of drug in the blood that is measured after the drug is taken.
If the drug is taken as a single dose, the Cmin should be closed to zero.
If the drug is taken as a repeated dose, the Cmin should be the drug concentration right before the next dose.
Cmin is also called "Trough".
AUC (Area Under the Curve) - AUC is the area under the curve of the drug concentration over time. AUC represents the overall amount of drug in the bloodstream after a dose.
Since drug concentrations are measured with some time intervals, not continuously, The AUC is usually calculated with an approximation that simulates the actual the drug concentration curve.
t½ (Half Life) - t½ is the amount of time it takes for the drug concentration in the blood to decline by half. The half-life is among the most important PK measurements for how often a drug has to be dosed (once-a-day or twice-a-day, etc).
SS (Steady State) - SS means that a person has been on a drug for enough time (usually one to two weeks) so that the drug concentration is not building up in the bloodstream anymore.
MTC (Minimum Toxic Concentration) - MTC is the lowest concentration of drug in the blood that toxicity usually occurs.
MEC (Minimum Effective Concentration) - MEC is the lowest concentration of drug in the blood that is required for drug effect.
TW (Therapeutic Window) - TW is the range of drug concentration between the MEC (Minimum Effective Concentration) and the MTC (Minimum Toxic Concentration).
TI (Therapeutic Index) - TI refers to several indices that are used for measuring a drug's safety. Higher TI means a safer drug. Lower TI means a dangerous drug. Two examples of TI are:
Â
⇑⇑ PK/PD Tutorials
2021-11-01, 358👍, 1💬
Popular Posts:
How to download and instal Open Babel from source code on CentOS computers? I want to build the bina...
How to display the InChi string and InChi Key of the molecule in JSME editor? JSME does not offer an...
Molecule Summary: ID: FYI-1000039 SMILES: Received at FYIcenter.com on: 2020-04-21
How to generate the molecule structure in SDF format from a SMILES string? To help you to generate t...
What is molview.org? molview.org is a Website that offers MolView as an open source web application,...