What Is PK-PD Relation

Q

What Is PK-PD (Pharmacokinetic-Pharmacodynamic) relation?

✍: Guest

A

Since PK is mainly represented as a function of drug concentration over time, and PD is mainly represented as a function of drug efficacy over drug concentration, the PK-PD relation is represented as a function of by drug efficacy over time by merging the PK function and the PK function together.

The picture shows you how the PK function and the PK function can be merged into a single function to represent the PK-PD relation.

PK-PD Relation Function (Source: skepticalraptor.com)

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â‡’ What Are PK Related Terminologies

â‡ What Is PD (Pharmacodynamic)

â‡‘ PK/PD Basic Concepts

â‡‘â‡‘ PK/PD Tutorials

2021-11-01, 613👍, 1💬

PK/PD Basic Concepts
Where to find FAQ (Frequently Asked Questions) in understanding PK/PD (Pharmacokinetic/Pharmacodynam ic)Basic Concepts? Here is a list of tutorials to answer many frequently asked questions compiled by FYIcenter.com team in understanding PK/PD (Pharmacokinetic/Pharmacodynam ic)Basic Concepts. What I... 2021-04-17, 573👍, 0💬

What Is PK (Pharmacokinetic)
What Is PK (Pharmacokinetic)? PK (Pharmacokinetics) describes the drug concentration-time courses in body fluids resulting from administration of a certain drug dose. More precisely, PK describes how the body reacts to a drug in terms of ADME (Absorption, Distribution, Metabolism, and Excretion). In... 2021-05-16, 557👍, 0💬

Molecule FYI-1000357
Molecule Summary: ID: FYI-1000357 SMILES: C1=CC=C(C2=CC=CC=C12)[C@H](N1C C[C@H](CC1)C(=O)NCCC1=CC=C(C=C 1)Cl)CReceived at FYIcenter.com on: 2021-04-15 2021-05-16, 556👍, 0💬

What Is Drug ADME
What Is drug ADME (Absorption, Distribution, Metabolism, and Excretion)? Drug ADME (Absorption, Distribution, Metabolism, and Excretion) are primary steps the human body handles a drug in the body. Step 1. Drug absorption: This is how the drug enters the blood -- usually from tablets or capsules in ... 2021-11-01, 516👍, 1💬

Single Dose AUC Calculation
What Is Single Dose AUC Calculation? Single Dose AUC Calculation for Non-Compartmental Analysis (NCA) is relatively simple. There are 4 commonly used methods: Trapezoidal, Log-linear trapezoidal, Lagrange polynomial, and Purves, as described in "SAS Programming to Calculate AUC in Pharmacokinetic St... 2022-12-14, 477👍, 0💬

PK/PD Tutorials
Where to find molecule FAQ (Frequently Asked Questions)? I want to learn more about PK/PD (Pharmacokinetic/Pharmacodynam ic).Here is a large collection of tutorials to answer many frequently asked questions compiled by FYIcenter.com team about PK/PD (Pharmacokinetic/Pharmacodynam ic):PK/PD Basic Con... 2021-04-17, 429👍, 0💬

Single Dose PK Dataset
Where Can I find an example of a single dose PK dataset? Here is an example of a single dose PK dataset published in "SAS Programming to Calculate AUC in Pharmacokinetic Studies" by John He. t0 t1 t2 t3 t4 t5 t6 t7 t8 t9 t10 t11 Time 0.00 0.25 0.50 0.75 1.00 1.50 2.00 3.00 4.00 6.00 8.00 12.00 Subje... 2022-11-04, 406👍, 0💬

Trapezoidal PK AUC Model
How to calculate PK AUC with linear trapezoidal model? The linear trapezoidal model to calculate PK AUC can be described as below: Assume that: t0, t1, t2, ..., t11 are times after dose C0, C1, C2, ..., C11 are drug concentrations at t0, t1, t2, ..., t11 AUC can be calculated as: AUC1 = 0.5*(t1-t0)*... 2022-11-04, 390👍, 0💬

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