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Single Dose AUC Calculation

Q

What Is Single Dose AUC Calculation?

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A

Single Dose AUC Calculation for Non-Compartmental Analysis (NCA) is relatively simple. There are 4 commonly used methods: Trapezoidal, Log-linear trapezoidal, Lagrange polynomial, and Purves, as described in "SAS Programming to Calculate AUC in Pharmacokinetic Studies" by John He.

**1. Trapezoidal Method** -
Trapezoidal Method uses a straight line connecting
two adjacent concentration-time points to simulate
the actual the drug concentration curve.

**2. Log-Linear Method** -
Log-Linear Method uses an exponential curve connecting
two adjacent concentration-time points to simulate
the actual the drug concentration curve.

**3. Lagrange Polynomial Method** -
Lagrange Polynomial Method uses a cubic polynominal conneting
four adjacent concentration-time points to simulate
the actual the drug concentration curve.

**3. Purves Method** -
Purves Method is an revised version of the Log-Linear method,
by using a parabola through the origin curve for the absorption phase.

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**â‡‘â‡‘** PK/PD Tutorials

2022-12-14, 572👍, 0💬

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